Sirolimus, also known as rapamycin, is an immunosuppressant drug that has been found to have efficacy in treating various skin disorders due to its anti-proliferative and anti-inflammatory properties.

It is used in the treatment of various skin conditions, such as psoriasis, atopic dermatitis, and cutaneous lupus erythematosus. It works by inhibiting the activation and proliferation of T-cells and other cells of the immune system that contribute to the inflammatory processes underlying these conditions